ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 22: Issue 4 (Feb 2024): Pregnancy and Kidney Disease is now available online.
RE: lupus management 12 minutes ago
Dr. Kim. We have pretty much gone full circle on this topic. A few known knowns, a lot of known unknowns and an uncounted number of unknown unknown...
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RE: Measuring individual kidney creatinine clearance 16 minutes ago
Sachin question If right kidney has significantly more function than left kidney, and we use same Cr of 0.7 as in this case to calculate individu...
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RE: Measuring individual kidney creatinine clearance 50 minutes ago
yes direct measurements in the hospital Urologist wanted nephrology to check 24 hour Cr Cl as pt got PCN and was in hospital already to decid...
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RE: PSGN in cirrhosis 1 hour ago
Excellent points Dr. Rodby. I was under the impression that all of the kidney abnormalities in this patients occurred early (within the first 8 wee...
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RE: Atypical Anti-GBM + MPO + IgA 1 hour ago
- Simply because - - - convenience of starting an oral agent CYC, versus difficulty and delays in getting insurance approvals and setting up infu...
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RE: PSGN in cirrhosis 2 hours ago
That EM had a very impressive hump. That is highly suggestive of a PSGN, but can be seen in C3 GN too that can mimic PSGN in adults (see attached) ...
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RE: Atypical Anti-GBM + MPO + IgA 4 hours ago
I agree with Dr.Aledan's assessment of the chronicity of the lesion in this case, but cellular crescents , mesangial and endocapillary hypercellula...
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RE: PSGN in cirrhosis 5 hours ago
Could you please clarify the results of IF for IgG, IgM, IgA, C3, C1q, C4 And kappa/lambda staining i tensity Thanks.. ------------------------...
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RE: PSGN in cirrhosis 6 hours ago
The whole picture is suggestive of IRGN and we need the results of kidney biopsy IF C3. Any other focus of infections suggestive of staphylococcus ...
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RE: Atypical Anti-GBM + MPO + IgA 6 hours ago
Great insightful comments from Dr Glassock, but do immunosuppressive therapy be still a valid option with such severe IFTA 65-75% and global GS (14...
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RE: lupus management 6 hours ago
This is an important contribution but it is a single center study from China, and needs to be confirmed in other cohorts of LN. The application of ...
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RE: lupus management 6 hours ago
Very interesting discussions! I am with the line of non-treater of clinically stable, serologically active disease. The long term outcome of any gl...
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RE: lupus management 9 hours ago
How about the utility of AI models to predict renal relapse? https://bmjopen.bmj.com/content/bmjopen/14/3/e071821.full.pdf?with-ds=yes ----...
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RE: Atypical Anti-GBM + MPO + IgA 12 hours ago
Sorry I neglected to comment on the IgA deposition. This is glomerular IgA deposition without any C3 deposition and no mesangial ED deposits by EM....
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RE: Atypical Anti-GBM + MPO + IgA 13 hours ago
Thanks Dr Glassock I will do my best to get these more sensitive serology. I will start him on oral CYC + steroids soon. Does presen...
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RE: lupus management 13 hours ago
Thank for the post. This test is non- specific for SLE , as it well be positive in many non-SLE disease with active systemic features.. I am unable...
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RE: Atypical Anti-GBM + MPO + IgA 13 hours ago
Making a "diagnosis " of atypical anti-GBM disease is very tricky business. It is NOT a Pathologic diagnosis per se as, by definition , it requires...
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RE: lupus management 15 hours ago
there is a new test called Progentec Lupus Disease Activity Index, P is measures basically 10 serum proteins and gives a score from -100 to 100 ...
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RE: PSGN in cirrhosis 17 hours ago
C4 is normal so unlikely that C3 hypo complementemia is due to a synthetic defect from hepatic cirrhosis. Synthetic defect will affect both c3 and ...
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RE: PSGN in cirrhosis 17 hours ago
Very, very unlikely that this degree of C3 hypo complementemia is due to a synthetic defect from hepatic cirrhosis. -----------------------------...
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Atypical Anti-GBM + MPO + IgA 19 hours ago
70 yowm a Vietnam Veteran HTN CAD developed leg swelling in November 2023. PCP decreased his Norvasc and added HCTZ. Edema did not improve and he w...
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RE: Dialysis in delayed presentation of EG ingestion 21 hours ago
Thanks Dr. Foster for your insights - I would love to talk with you at some point about your experiences with EG poisoning in animals! Not surpri...
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RE: Dialysis in delayed presentation of EG ingestion 22 hours ago
We have seen less EG toxicity in dogs, but this is something we've encountered for decades. Dialyzing them shortly after ingestion has favorable ou...
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RE: PSGN in cirrhosis 22 hours ago
Could low C3 be due to decreased production by the cirrhotic liver rather than consumption? Thanks ------------------------------ Mowaffaq ----...
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RE: PSGN in cirrhosis 1 day ago
Seems surprising that no C3 deposition was seen on IF. Especially with such strong stain for IGA and IgG ------------------------------ Satish Ba...
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RE: Lupus In pregnancy 1 day ago
Thanks- with a complete clinical and serological remission and no relapses for 4 years, the risk of a shift to AzA and/or a pregnancy provoking a r...
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RE: Lupus In pregnancy 1 day ago
No urine analysis negative done on same setting ESR / CRP not elevated c3/c3 never consumed attached her previous biops...
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RE: Lupus In pregnancy 1 day ago
Thanks- the absence of hydroxychloroquine therapy may increase the risks of a relapse a bit , but I would not increase the steroids until she is pr...
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RE: ASN Kidney News Editorial Fellowship 1 day ago
hola interesado en la beca soy colombiano ------------------------------ Juan Conde DrMed CLINICA DE LA COSTA BARRANQUILLA 57 3008370746 -------...
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RE: Lupus In pregnancy 1 day ago
Thanks a lot for this useful discussion Actually she has no relapses for 4 years , I switched to Azathioprine 2mg/kg yesterday she was ...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 1 day ago
Thanks All for your feedback so will watch him on supportive care I guess main question he already has several risk factors for his CKD progres...
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RE: PSGN in cirrhosis 1 day ago
See this 30 year old paper. Nothing new under the sun. Keller CK, et al, Q. JMed 1994; 87: 97-102. The association of PSGN with alcoholic cirrhosis...
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RE: PSGN in cirrhosis 1 day ago
What about the possibility of PSGN superimposed on a pre-existing hepatic Glomerulopathy ? . Difficult to prove, but entirely reasonable . There ar...
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RE: Dialysis in delayed presentation of EG ingestion 1 day ago
It would seem that once a calcium oxalate crystal is formed/deposited in the interstitium of the kidney (and other organs ) following a bot of acut...
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PSGN in cirrhosis 1 day ago
We would be interested in your opinion on this case: A 54-year-old man, recently diagnosed with alcoholic liver cirrhosis, presented with abdomina...
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RE: Dialysis in delayed presentation of EG ingestion 1 day ago
Agree that this is a late presentation since a creatinine of 14 would require days to evolve (assuming normal baseline kidney function) as evidence...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 1 day ago
Dr. Vogt. Thanks- the Ballardie-Robert's finding of efficacy of CYC -steroids in non-crescentic IgA N (not IgAV) was not confirmed by the STOP-IgAN...
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RE: Lupus In pregnancy 1 day ago
in addition to changing MMF to azathioprine, and bumping up the steroids a bit (maybe total 15-20/d?) and checking for APAbs , I would add aspirin ...
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RE: LAST CALL: Volunteer by TODAY May 8 to serve as a case report reviewer for Kidney Week 2024! 1 day ago
Is it still possible to be a fellow reviewer? Patrick Sent from my iPhone
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RE: Dialysis in delayed presentation of EG ingestion 2 days ago
That is a rough case. The largest cohort of patients with AKI after ethylene glycol poisoning who required dialysis that I am aware of is in an a...
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RE: Lupus In pregnancy 2 days ago
Hi there I would like to talk to you about lupus nephritis.It is very much common in females with 9:1 ratio and is being graded according to Histop...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
PS: We still give cyclophosphamide in severe cases, most when visceral involvement not studies in the Pillebout et al. publication, see pic attache...
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RE: Lupus In pregnancy 2 days ago
Thanks Dr. Vogt for your comment. I should add that patients with SLE, with or without LN should be tested for anti-phospholipid antibodies as t...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
Thank you Prof. Glassock. This publicaiton I always have difficulties to find! This and the Ballardie paper are the two main publications on this t...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
Thanks Dr. Vogt. A single RCT of CYC aded to steroids showed no efficacy imn adults with severe IgAV (see Pillebout, E et al Kidney Int, 2010. ) ...
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RE: lupus management 2 days ago
Thanks for the clarification. Thus , the ability to predict a relapse of LN from serology varies from patient to patient. In some patients the corr...
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RE: lupus management 2 days ago
In this patient I cannot quantify the risk of relapse .. But if a patient relapses after I month or 2 months ( less or more) of serological activit...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
The rash in legs, with IgA in skin biopsy is Henoch Schönlein purpura. Usually, the skin lesions in adult are not purpura but small necrosis and in...
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RE: lupus management 2 days ago
Thank you for valuable comments! At the time of diagnosis, dsDNA ~300, C3 31 C4 2. Upcr 2.3. I guess she is not there yet at least serologicall...
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RE: Lupus In pregnancy 2 days ago
We do exactly what Prof Glassock proposed, switching from MMF to Azathioprine. Intensification of steroid dosing after conception may be appropriat...
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