ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 22: Issue 4 (Feb 2024): Pregnancy and Kidney Disease is now available online.
RE: Duration of immunosuppression in PR3 ANCA vasculitis 1 hour ago
Thanks Dr Glassock CRP ESR WBC normal Did not check IgG and CD19 Will do 5 years and then will stop and monitor She already been on it for 4 year...
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RE: Duration of immunosuppression in PR3 ANCA vasculitis 2 hours ago
Don't be surprised if you receive a variety of opinion concerning your question. This is one (of many) evidence free zones in the topic of manageme...
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RE: PSGN in cirrhosis 3 hours ago
If the C3 level does not return to normal by 8 weeks, I think that genetic studies for C-regulation mutations, a C3NEF assay , an anti-Factor B and...
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RE: PSGN in cirrhosis 7 hours ago
C3 may take 6 to 8 weeks before it becomes normal --------------------------------- Shahzad Safdar MD MD Mt. Auburn Nephrology, Inc. Cincinnat...
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RE: Guidance about further dosing recurrent PR3 ANCA vasculitis And Risk Of Infection 7 hours ago
Thanks Dr Venkat This is very helpful No Cd19 was not checked in 2019 --------------------------------- Shahzad Safdar MD MD Mt. Auburn Nephrol...
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RE: Guidance about further dosing recurrent PR3 ANCA vasculitis And Risk Of Infection 8 hours ago
Was CD19/20 checked during episode of iritis in 2019? If it was elevated then, one can conclude that CD19/20 reappearance correlates with disease a...
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RE: PSGN in cirrhosis 8 hours ago
"IF results showed IgA (4+), IgG (3+), IgM (trace), kappa and lambda light chains (3+) and C3 (3+) while C1q and albumin are negative." If IgA wa...
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RE: PSGN in cirrhosis 8 hours ago
IF results showed IgA (4+), IgG (3+), IgM (trace), kappa and lambda light chains (3+) and C3 (3+) while C1q and albumin are negative. Dr. Rodby,...
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Guidance about further dosing recurrent PR3 ANCA vasculitis And Risk Of Infection 10 hours ago
79-year-old caucasian female diagnosed with PR3 ANCA vasculitis in 3/2015 main symptoms were double vision due to 6 th nerve palsy some ear problem...
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Duration of immunosuppression in PR3 ANCA vasculitis 11 hours ago
I would appreciate experts help in this patient I have 57-year-old Caucasian female diagnosed with PR3 ANCA vasculitis on kidney biopsy in 12/2019...
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RE: Measuring individual kidney creatinine clearance 14 hours ago
After PERC post obstructive drainage have you reached steady state level and collection has to be perfectly carried out by staff which is crucial ...
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RE: Measuring individual kidney creatinine clearance 14 hours ago
Very true. If the R kidney were removed (by accident of course, not intentionally) the serum creatinine AND UV creatinine (from the remaining L kid...
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RE: lupus management 15 hours ago
Dr. Kim. We have pretty much gone full circle on this topic. A few known knowns, a lot of known unknowns and an uncounted number of unknown unknown...
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RE: Measuring individual kidney creatinine clearance 15 hours ago
Sachin question If right kidney has significantly more function than left kidney, and we use same Cr of 0.7 as in this case to calculate individu...
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RE: Measuring individual kidney creatinine clearance 15 hours ago
yes direct measurements in the hospital Urologist wanted nephrology to check 24 hour Cr Cl as pt got PCN and was in hospital already to decid...
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RE: PSGN in cirrhosis 16 hours ago
Excellent points Dr. Rodby. I was under the impression that all of the kidney abnormalities in this patients occurred early (within the first 8 wee...
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RE: Atypical Anti-GBM + MPO + IgA 16 hours ago
- Simply because - - - convenience of starting an oral agent CYC, versus difficulty and delays in getting insurance approvals and setting up infu...
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RE: PSGN in cirrhosis 16 hours ago
That EM had a very impressive hump. That is highly suggestive of a PSGN, but can be seen in C3 GN too that can mimic PSGN in adults (see attached) ...
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RE: Atypical Anti-GBM + MPO + IgA 19 hours ago
I agree with Dr.Aledan's assessment of the chronicity of the lesion in this case, but cellular crescents , mesangial and endocapillary hypercellula...
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RE: PSGN in cirrhosis 20 hours ago
Could you please clarify the results of IF for IgG, IgM, IgA, C3, C1q, C4 And kappa/lambda staining i tensity Thanks.. ------------------------...
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RE: PSGN in cirrhosis 20 hours ago
The whole picture is suggestive of IRGN and we need the results of kidney biopsy IF C3. Any other focus of infections suggestive of staphylococcus ...
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RE: Atypical Anti-GBM + MPO + IgA 21 hours ago
Great insightful comments from Dr Glassock, but do immunosuppressive therapy be still a valid option with such severe IFTA 65-75% and global GS (14...
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RE: lupus management 21 hours ago
This is an important contribution but it is a single center study from China, and needs to be confirmed in other cohorts of LN. The application of ...
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RE: lupus management 21 hours ago
Very interesting discussions! I am with the line of non-treater of clinically stable, serologically active disease. The long term outcome of any gl...
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RE: lupus management 1 day ago
How about the utility of AI models to predict renal relapse? https://bmjopen.bmj.com/content/bmjopen/14/3/e071821.full.pdf?with-ds=yes ----...
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RE: Atypical Anti-GBM + MPO + IgA 1 day ago
Sorry I neglected to comment on the IgA deposition. This is glomerular IgA deposition without any C3 deposition and no mesangial ED deposits by EM....
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RE: Atypical Anti-GBM + MPO + IgA 1 day ago
Thanks Dr Glassock I will do my best to get these more sensitive serology. I will start him on oral CYC + steroids soon. Does presen...
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RE: lupus management 1 day ago
Thank for the post. This test is non- specific for SLE , as it well be positive in many non-SLE disease with active systemic features.. I am unable...
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RE: Atypical Anti-GBM + MPO + IgA 1 day ago
Making a "diagnosis " of atypical anti-GBM disease is very tricky business. It is NOT a Pathologic diagnosis per se as, by definition , it requires...
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RE: lupus management 1 day ago
there is a new test called Progentec Lupus Disease Activity Index, P is measures basically 10 serum proteins and gives a score from -100 to 100 ...
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RE: PSGN in cirrhosis 1 day ago
C4 is normal so unlikely that C3 hypo complementemia is due to a synthetic defect from hepatic cirrhosis. Synthetic defect will affect both c3 and ...
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RE: PSGN in cirrhosis 1 day ago
Very, very unlikely that this degree of C3 hypo complementemia is due to a synthetic defect from hepatic cirrhosis. -----------------------------...
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Atypical Anti-GBM + MPO + IgA 1 day ago
70 yowm a Vietnam Veteran HTN CAD developed leg swelling in November 2023. PCP decreased his Norvasc and added HCTZ. Edema did not improve and he w...
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RE: Dialysis in delayed presentation of EG ingestion 1 day ago
Thanks Dr. Foster for your insights - I would love to talk with you at some point about your experiences with EG poisoning in animals! Not surpri...
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RE: Dialysis in delayed presentation of EG ingestion 1 day ago
We have seen less EG toxicity in dogs, but this is something we've encountered for decades. Dialyzing them shortly after ingestion has favorable ou...
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RE: PSGN in cirrhosis 1 day ago
Could low C3 be due to decreased production by the cirrhotic liver rather than consumption? Thanks ------------------------------ Mowaffaq ----...
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RE: PSGN in cirrhosis 1 day ago
Seems surprising that no C3 deposition was seen on IF. Especially with such strong stain for IGA and IgG ------------------------------ Satish Ba...
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RE: Lupus In pregnancy 1 day ago
Thanks- with a complete clinical and serological remission and no relapses for 4 years, the risk of a shift to AzA and/or a pregnancy provoking a r...
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RE: Lupus In pregnancy 1 day ago
No urine analysis negative done on same setting ESR / CRP not elevated c3/c3 never consumed attached her previous biops...
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RE: Lupus In pregnancy 1 day ago
Thanks- the absence of hydroxychloroquine therapy may increase the risks of a relapse a bit , but I would not increase the steroids until she is pr...
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RE: ASN Kidney News Editorial Fellowship 1 day ago
hola interesado en la beca soy colombiano ------------------------------ Juan Conde DrMed CLINICA DE LA COSTA BARRANQUILLA 57 3008370746 -------...
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RE: Lupus In pregnancy 1 day ago
Thanks a lot for this useful discussion Actually she has no relapses for 4 years , I switched to Azathioprine 2mg/kg yesterday she was ...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
Thanks All for your feedback so will watch him on supportive care I guess main question he already has several risk factors for his CKD progres...
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RE: PSGN in cirrhosis 2 days ago
See this 30 year old paper. Nothing new under the sun. Keller CK, et al, Q. JMed 1994; 87: 97-102. The association of PSGN with alcoholic cirrhosis...
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RE: PSGN in cirrhosis 2 days ago
What about the possibility of PSGN superimposed on a pre-existing hepatic Glomerulopathy ? . Difficult to prove, but entirely reasonable . There ar...
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RE: Dialysis in delayed presentation of EG ingestion 2 days ago
It would seem that once a calcium oxalate crystal is formed/deposited in the interstitium of the kidney (and other organs ) following a bot of acut...
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PSGN in cirrhosis 2 days ago
We would be interested in your opinion on this case: A 54-year-old man, recently diagnosed with alcoholic liver cirrhosis, presented with abdomina...
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RE: Dialysis in delayed presentation of EG ingestion 2 days ago
Agree that this is a late presentation since a creatinine of 14 would require days to evolve (assuming normal baseline kidney function) as evidence...
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RE: IgA Nephritis and pneumonia, underlying CKD with co morbidities 2 days ago
Dr. Vogt. Thanks- the Ballardie-Robert's finding of efficacy of CYC -steroids in non-crescentic IgA N (not IgAV) was not confirmed by the STOP-IgAN...
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RE: Lupus In pregnancy 2 days ago
in addition to changing MMF to azathioprine, and bumping up the steroids a bit (maybe total 15-20/d?) and checking for APAbs , I would add aspirin ...
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