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Growth in children with chronic kidney disease: 13 years follow up study

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Abstract

Background

Growth retardation is one of the most visible comorbid conditions of chronic kidney disease (CKD) in children. To our knowledge, published data on longitudinal follow-up of growth in pediatric patients with CKD is lacking from the region of South-East Europe. Herein we report the results from the Serbian Pediatric Registry of Chronic Kidney Disease.

Methods

The data reported in the present prospective analysis were collected between 2000 and 2012. A total of 324 children with CKD were enrolled in the registry.

Results

Prevalence of growth failure at registry entry was 29.3 %. Mean height standard deviation scores (HtSDS) in children with stunting and those with normal stature were −3.00 [95 % confidence interval (CI) −3.21 to −2.79] and −0.08 (95 % CI −0.22 to 0.05) (p < 0.001), respectively. Children with hereditary nephropathy had worse growth at registration (−1.51; 95 % CI −1.97 to −1.04, p = 0.008). Those with CKD stages 4 and 5 before registration had more chance to have short stature at registration than those with CKD stages 2 and 3 [odds ratio (OR) = 0.458, CI 0.268–0.782, p = 0.004]. Dialysis was an independent negative predictor for maintaining optimal stature during the follow-up period (OR = 0.324, CI = 0.199–0.529, p < 0.001), while transplantation was an independent positive predictor for improvement of small stature during follow-up (OR = 3.706, CI = 1.785–7.696, p < 0.001).

Conclusion

Growth failure remains a significant problem in children with CKD, being worst in patients with hereditary renal disease. Growth is not improved by standard dialysis, but transplantation has a positive impact on growth in children.

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Acknowledgments

We thank Jelena Bubalo, Mirjana Kostić, Maja Kovačević, Divna Kruščić, Gordana Miloševski-Lomić, Predrag Miljković, Marko Petrović, Jovana Putnik, Snežena Radisavljević, Brankica Spasojević, Nataša Stajić, Vesna Stojanović and Milesa Dapić for their help in making SPRECKID. This work was financially supported by a grant from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project Number 175079).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Medical Faculty, University of Belgrade, Belgrade, Serbia

    Petar Salević, Pavle Radović, Nataša Milić, Radovan Bogdanović & Amira Peco-Antić

  2. Institute of Mother and Child Health Care of Serbia “Dr Vukan Čupić”, Belgrade, Serbia

    Radovan Bogdanović & Aleksandra Paripović

  3. University Children’s Hospital, Belgrade, Serbia

    Dušan Paripović & Amira Peco-Antić

  4. Medical Faculty of University of Niš, Niš, Serbia

    Emilija Golubović

  5. Medical Faculty of University of Novi Sad, Novi Sad, Serbia

    Biljana Milosević

  6. Pediatric Department of the Hospital, Novi Pazar, Serbia

    Bilsana Mulić

  7. Institute for Medical Statistics and Informatics, Belgrade University School of Medicine, Belgrade, Serbia

    Nataša Milić

  8. Pediatric Intensive Care Unit, University Children’s Hospital, Tiršova 10, 11000, Belgrade, Serbia

    Petar Salević

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  1. Petar Salević
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Correspondence to Petar Salević.

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On Behalf of the SPRECKID Registry.

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Salević, P., Radović, P., Milić, N. et al. Growth in children with chronic kidney disease: 13 years follow up study. J Nephrol 27, 537–544 (2014). https://doi.org/10.1007/s40620-014-0094-8

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  • DOI: https://doi.org/10.1007/s40620-014-0094-8

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